Molecular Systems Engineering of Algae – The Construction of Molecular Factories Based on a Phototroph Platform

  • Molecular systems engineering of the green algae Chlamydomonas could potentially produce value-added compounds so far not generated by microorganisms, such as structurally complex alkaloids.
    Molecular systems engineering of the green algae Chlamydomonas could potentially produce value-added compounds so far not generated by microorganisms, such as structurally complex alkaloids.

The main goal of this project is to engineer the cell surface of algae, to generate new phenotypes and to construct molecular factories based on a phototrophic platform.

Algae offer unique opportunities as programmable (by light) CO2-fixing organisms that can be grown for example, on brackish or waste water with concomitant CO2 fixation from fossil fuel power plants and the ability to produce biofuels or value added chemicals.
The question raised by this project is if this potential can be leveraged by Molecular Systems Engineering to increase the efficiency, sustainability and productivity of the phototrophic organisms. Ultimately, the goal is to construct molecular factories based on a phototroph platform.

Articles

Y. CotelleN. Chuard, S. Lascano, V. Lebrun, R. Wehlauch, N. Bohni, S. Lörcher, V. Postupalenko, S. ReddyW. MeierC. G. PalivanK. GademannT. R. WardS. MatileInterfacing Functional Systems“ Chimia 6, 418 (2016). [Link]
C. E. HousecroftC. G. PalivanK. GademannW. MeierM. CalameV. Mikhalevich, X. Zhang, E. PielM. SzponarskiA. WieslerA. Lanzilotto, E. C. Constable, A. Fanget, R. Stoop “‘Active surfaces’ as Possible Functional Systems in Detection and Chemical (Bio) Reactivity“ Chimia 6, 402 (2016). [Link]
S. Lascano, K. Zhang, R. Wehlauch, K. Gademann, N. Sakaiab, S. MatileThe third orthogonal dynamic covalent bond“ Chem. Sci. 7, 4720 (2016). [Link]
E. Kaufmann, H. Hattori, H. Miyatake-Ondozabal, K. GademannTotal Synthesis of the Glycosylated Macrolide Antibiotic Fidaxomicin“ Org. Lett. 17, 3514 (2015). [Link]
K. GademannNatural Product Approaches to Biomaterials and Neuroengineering“ Acc. Chem. Res. 48, 731 (2015). [Link]
H. Miyatake-Ondozabal, E. Kaufmann, K. GademannTotal Synthesis of the Protected Aglycon of Fidaxomicin (Tiacumicin B, Lipiarmycin A3)“ Angew. Chem. Int. Ed. 54, 1933 (2015). [Link]

Who works with whom?

Prof. Karl Gademann from the University of Zurich (Department of Chemistry) leads this project and works with postdoc student Nadine Bohni and with PhD-students Ellen Piel and Mathieu Szponarski.

Group

Read more about the Gademann-Group here.

Collaborations

The phototroph-based platform will be developed in collaboration with and used by projects led by Daniel Müller, Wolfgang Meier, Sven Panke, Michel Calame, Thomas R. Ward, Martin Fussenegger, Dimitrios Fotiadis, Roderick Lim, Stefan Matile, Marcel Mayor, Francesco Stellacci, and Catherine Housecroft.